While teplizumab has the potential to be a new type of diabetes medicine, it’s had a checkered past, and the contingencies in the deal with Sanofi reflect that. In 2010, Eli Lilly and partner MacroGenics were developing the drug and decided to shelve it after a study failed to reduce insulin use in patients with recent-onset Type 1 diabetes.
Provention got interested as continuing academic studies suggested benefits for the drug and bought the rights in 2018. By 2019, the purchase seemed like a good bet as researchers published a study in The New England Journal of Medicine that found the drug could delay the onset of disease with a single 14-day course of treatment.
The trial included 76 relatives of Type 1 diabetes patients who were themselves at high risk of developing the disease. Many of the patients went on to be diagnosed with the condition, but the median time to diagnosis for patients taking teplizumab was four years, compared with two years in the placebo group. READ MORE
By Kristin Jensen
The Food and Drug Administration’s top scientist Namandjé Bumpus will assume the role of principal deputy commissioner when longtime agency leader Janet Woodcock retires from that role in early 2024, according to an announcement Thursday.
US biopharma AbbVie has agreed to acquire ImmunoGen in a deal which values the company at about $10.1 billion and gives AbbVie access to flagship cancer therapy Elahere (mirvetuximab soravtansine-gynx), a first-in-class antibody-drug conjugate (ADC) approved for platinum-resistant ovarian cancer (PROC), as well as a pipeline of promising next-generation ADCs.
EUROAPI today announced the appointment of David Seignolle as Chief Operating Officer, succeeding Eric Berger, and Marion Santin as Chief Legal, Compliance, and IP Officer, both joining the company’s Executive Committee. In his new role, David Seignolle will lead the transformation of the Industrial Operations organization.