Sector News

Sanofi cuts ties with Sangamo, sharpening focus on ‘off-the-shelf’ cell therapy

January 15, 2022
Life sciences

Through a spate of dealmaking over the past few years, Sanofi has made its intentions in the gene and cell therapy field clear. The company seems uninterested in hard-to-manufacture treatments that consist of individual patient cells genetically modified outside the body, instead favoring ones meant to be used “off the shelf.”

In 2020, for instance, the French drugmaker bought Kiadis Pharma, which is working on more convenient cell treatments for cancer. Sanofi acquired another off-the-shelf cell therapy developer, Tidal Therapeutics, the following year, and envisions its recent investments in messenger RNA technology as aiding in the effort.

In doing so, Sanofi isn’t just bypassing the first generation of so-called CAR-T therapies, which are powerful tools against certain blood cancers but are limited by their complexity. It’s also casting aside outside-the-body treatments for genetic diseases, a class that includes drugs from CRISPR Therapeutics and Bluebird bio that have shown considerable promise treating blood diseases like beta thalassemia and sickle cell. READ MORE

By Ben Fidler


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