Sector News

NeRRe splits in two, carving out women’s health company

September 27, 2017
Life sciences

U.K. biotech NeRRe Therapeutics has decided to streamline its R&D portfolio by setting up a brand-new company focusing on women’s health.

The new company, called KaNDy Therapeutics, makes its official debut today and will handle the development of NT-814, one of two phase 2 candidates developed at NeRRe. It is billed as a first-in-class neurokinin-1,3 receptor antagonist with potential to treat postmenopausal vasomotor symptoms (PMVMS) such as hot flashes and sleep disturbances.

That leaves NeRRe—which itself spun out of GlaxoSmithKline (GSK) in 2012 after the big pharma company decided to withdraw from neuroscience R&D—focusing its activities on its NK-1 antagonist program for neuronal hypersensitivity headed by orvepitant.

The new company’s managing director, Mary Kerr, who moved to NeRRe from GSK, explained the reason for the decision to bisect the business. “It was clear during the series B raise that very few investors had an interest to invest in both sides of the NeRRe portfolio. In fact, one year ago it was difficult to find anyone interested in women’s health at all, but that has changed in recent months,” she told FierceBiotech, pointing to recent developments such as Astellas’ acquisition of PMVMS drug developer Ogeda and IPOs for endometriosis drug developer Myovant and ObsEva, a reproductive health specialist.

The two companies have the same shareholder base for now, but there is now flexibility for this to diversify and extend if necessary, and separating out NT-814 will provide “differential investment, including access to capital and IPO markets.”

NT-814 has the potential to become an important new therapeutic in women’s health, as neurokinin antagonism represents one of the few novel targets in the sector for more than two decades and could become a once-daily, nonhormonal therapy for postmenopausal symptoms.

The drug is heading for a phase 2b trial that will test its ability to reduce the frequency and severity of hot flashes at four and 12 weeks, with results expected within the next 12 to 18 months. In that time frame, KaNDy may also start initial studies in potential follow-up indications, which could include endometriosis and polycystic ovary syndrome.

“For many women, menopausal symptoms such as hot flashes are debilitating and long-lasting, and can have a major impact on quality of life,” said Professor Richard Anderson, a women’s health specialist at the University of Edinburgh and clinical adviser to KaNDy, in a release. “As a potential once-daily alternative to HRT without the issues surrounding hormone replacement, NT-814 could bring them considerable relief.”

KaNDY is chaired by Iain Dukes, venture partner at OrbiMed, and is based at the Stevenage Bioscience Catalyst in the U.K.

By Phil Taylor

Source: Fierce Biotech

comments closed

Related News

October 17, 2021

Colorcon acquires a majority share in Ideal Cures Pvt. Ltd., India

Life sciences

Ideal Cures will operate as a fully independent entity within Colorcon. Their business complements Colorcon’s position in the Indian pharmaceutical market with a strong presence in the domestic generic sector comprised of long-standing customer relationships sustained by innovative and customized solutions.

October 17, 2021

Barriers exist, but participation urgent in breast cancer clinical trials: report

Life sciences

Across four new breast cancer treatments approved by the FDA last year, 2% to 9% of patients in clinical trials for the drugs were Black Americans and 0% to 9% were Hispanic, according to a new report from Breastcancer.org.

October 17, 2021

Danish consortium acquires part of Jernbanebyen to create one of the world’s healthiest urban villages

Life sciences

The southern section of Jernbanebyen in central Copenhagen has a new owner. The Baneby Consortium, comprising NREP, Novo Holdings and Industriens Pension, has bought the land from Freja Ejendomme. The ambition is to create a green, partly car-free environment that will also be one of the healthiest in the world. 

Send this to a friend