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Horizon looks to the future with massive San Francisco manufacturing, R&D plant

December 4, 2019
Life sciences

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Horizon Therapeutics, once known for its primary care drugs, is looking to pivot further to rare diseases with the FDA scrutinizing its late-stage inflammatory eye disease candidate. In the meantime, Horizon is, well, looking to the horizon with a new manufacturing and R&D facility that could help boost its growing pipeline.

Horizon recently opened a 20,000-square-foot facility in South San Francisco that will “feature laboratory space that will enable formulation and process development for manufacturing, as well as bioanalytical method development and other R&D functions,” the company said in a release.

The Irish drugmaker said its position in the city’s well-traveled biotech hub would allow it to form new partnerships with existing companies and institutions in the area.

“We are excited to join the thriving life sciences community of South San Francisco, allowing us the opportunity to connect to newer technologies, leading academic institutions and the dynamic scientific area at large,” Horizon CEO and chairman Timothy Walbert said.

The company didn’t disclose the price of the project or the number of employees that would be hired on but did say it planned to “add new positions in bioanalysis, clinical research, pharmacology, manufacturing and business development during the next year.”

Horizon is taking the plunge in San Francisco as it awaits an FDA priority review for inflammatory eye drug teprotumumab.

In June, Horizon said it planned to add around 40 to 45 sales rep positions in expectation of the drug’s approval. As of that time, Horizon said about 1,200 had submitted their resumes.

Teprotumumab is designed to treat thyroid eye disease (TED), where inflammation in the eyes causes symptoms such as double vision and eye bulging. Horizon got the drug through its $145 million acquisition of River Vision in 2017 on the heels of positive phase 2 results.

In September, the med received a priority review designation from the FDA, putting it on the fast course to an approval. Jefferies analysts said the drug could settle in around $150,000 per course of treatment once it hits the market.

The teprotumumab sales team will target 6,000 to 7,000 physicians, including 700 ocular plastic surgeons. Currently, patients often progress into inactive TED and could undergo surgery to reduce bulging eyes, Walbert told analysts in June.

Horizon recently began to shift its portfolio from primary care to one heavy in rare diseases and rheumatology. Primary care drugs made up 85% of sales in 2014, while rare disease assets contributed 69% to the company’s 2018 revenues, the Jefferies analysts noted. And to mark its transition to an R&D-focused strategy, the company just recently changed the ending of its name from “Pharma” to “Therapeutics.”

While Horizon continues to look at potential acquisitions, management believes it can still double revenues from the existing portfolio in the coming years, driven mainly by teprotumumab and gout drug Krystexxa, Jefferies said.

By Kyle Blankenship

Source: Fierce Pharma

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