Sector News

AbbVie, Genmab, with new data, prep FDA application for dual-acting cancer drug

April 16, 2022
Life sciences

Yescarta and Kymriah, known as CAR-T therapies, can help cancer patients by arming their immune cells to attack diseased tissue in types of lymphoma and leukemia. But, because the immune cells must be genetically engineered outside the body, treatment is lengthy, complicated and expensive.

The dual-acting, or “bispecific,” antibodies being developed by AbbVie and Genmab, Roche, and other companies like Johnson & Johnson and Regeneron, latch onto proteins on both diseased and immune cells to trigger an attack. Unlike CAR-T drugs, which are meant to be a one-time infusion, bispecific antibodies must be given regularly. In the case of this epcoritamab trial, patients received a subcutaneous shot every four weeks.

Data from 157 patients with large B cell lymphoma reported Wednesday showed that 63% responded to treatment with epcoritamab, although the company didn’t detail how many were driven into remission versus experiencing partial responses. In order to be included in the trial, patients had to have relapsed after at least two lines of therapy. Nearly 40% had previously received CAR-T treatment. READ MORE

by Jonathan Gardner


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