Oncology tests in the U.S. are still failing to adequately represent racial diversity, and more needs to be done to help combat this disparity, according to new research.
Writing in the JAMA Oncology journal, investigators delved into the reporting and representation of the racial make-up of those involved in 230 trials through a 10-year period between 2008 and 2018 testing cancer drugs that were later approved by the FDA.
Across these, race was reported in only 145 (63%) trials, according to their findings, compared with whites (98% of expected proportion), blacks (22% of expected proportion) and Hispanics (44% of expected proportion).
They found that while black and Hispanic patients “were consistently underrepresented compared with their expected proportion based on cancer incidence and mortality in the United States,” but Asian patients “appeared to be overrepresented,” while white patients pretty much matched their expected proportion.
They conclude that: “Despite efforts to eliminate health care disparities, gaps in race reporting and disparate representation persist in oncology trials. Black and Hispanic patients are consistently underrepresented relative to the U.S. population in trials used for FDA cancer drug approvals.
“Reducing cancer care disparities is a multidimensional task that extends beyond trial accrual and reporting, and there is a pressing need for affirmative policies, dedicated disparity research, and social/regulatory interventions to increase representation of minority groups in cancer research. Given the growing racial and ethnic pluralism in society, it is a scientific and ethical imperative to ensure that our research reflects and benefits all.”
By Ben Adams
Source: Fierce Biotech
The United Arab Emirates (UAE) Ministry of Health and Prevention (MoHAP) has established a partnership with Novo Nordisk Pharma Gulf focusing on the creation of a national scientific guide for obesity management and weight control. The collaboration also aims to enhance public awareness of cardiovascular diseases and their complications.
Pharma giant Eli Lilly is teaming up with Haya Therapeutics in a $1bn deal to find multiple regulatory-genome-derived RNA-based drug targets, as it eyes up new targets in obesity. Under the deal, the companies will use Haya’s proprietary regulatory genome discovery platform to identify and validate long non-coding RNA (lncRNA) targets for developing potential treatments for obesity and related metabolic disorders.
The sale includes custom formulation and contract manufacturing capabilities for the nutrition market from the production facilities in New Jersey and Utah in the United States, and Tamaulipas, Mexico. Financial terms of the transaction were not disclosed.
