Sanofi made a splash in rare disease R&D when it traded $20 billion for Genzyme in 2011, and now the French drugmaker is on the hunt for deals “up to” that size as acquisitive rival Shire angles to dominate the space.
Speaking to the Financial Times, Genzyme CEO David Meeker said the company is surveying the field of rare disease-focused biotech companies, declining to name names. A months-long slump in valuations has made once-pricey targets suddenly more affordable, but Sanofi isn’t feeling pressure to close an acquisition before a potential turnaround, Meeker said.
Among the mid-size players in rare disease are BioMarin Pharmaceuticals, which commands a market cap of around $13 billion, plus Ionis Pharmaceuticals and Ultragenyx, which are worth roughly $4 billion and $2.5 billion, respectively.
The idea dovetails with Sanofi’s recent statements on how it plans to reverse its slumping growth, as recently appointed CEO Olivier Brandicourt has repeatedly said the company is interested in deals big and small to counteract creeping competition and sluggish sales for its banner products.
And rare diseases could be an ideal field to boost Sanofi’s margins. Orphan drugs like Genzyme’s Cerezyme treat small numbers of patients but command high prices, and insurers have traditionally been willing to shell out for such therapies on the belief that they prevent costlier outcomes for sufferers of rare disease. And Meeker is betting those dynamics are unlikely to change despite the furor over drug pricing in the U.S., arguing that the economics of orphan drugs keep the sector “relatively protected from the discussion.”
Meanwhile, the rare disease-focused Shire has signed a $32 billion merger agreement with Baxalta that the company said will make it the largest player in the space, promising to grow revenue to $20 billion by 2020.
By Damian Garde
Source: Fierce Biotech
The companies will explore opportunities to apply Flagship’s innovative bioplatforms – an ecosystem that currently comprises 41 companies – to scientific challenges in disease areas within cardiometabolic and rare diseases and initiate research programmes based on these.
BD is expanding its long-running partnership with the blood collection company Babson Diagnostics. The two companies have been working together since 2019 on a device that can gather small volumes of blood from the capillaries in the fingertip without requiring any specialized training, and beginning with a focus on supporting primary care in retail settings.
Wednesday, Australian biotech CSL said (PDF) the regulatory review of its $11.7 billion acquisition of Switzerland’s Vifor Pharma will take “a few more months,” suggesting it won’t be able to close the transaction by June 2022 as previously expected.
