San Diego biotech BioAtla is sharing its immuno-oncology assets with Pfizer in a deal worth up to $1 billion, mixing and matching technologies in hopes of hitting on a winning combination.
Under the agreement, BioAtla is handing over some of its conditionally active biologics, or CABs, which are immunotherapeutics that can be switched on in the presence of certain antigens. And Pfizer is bringing a stable of antibody-drug conjugates, or ADCs, which use antibodies to ferry treatments to specific targets. Combined, the partners believe they can craft CAB-powered ADCs that can more safely deliver cancer-killing drugs to a wide range of tumor types.
The plan is to split development and commercialization rights between the two companies, with each in line for milestone payments and royalties related to the other’s work. Pfizer is also in-licensing a CAB project that targets the protein CTLA-4, a so-called immune checkpoint that hampers the body’s ability to detect cancer. In exchange, the Big Pharma is promising BioAtla an untold up-front sum and down-the-road payments totaling as much as $1 billion.
For BioAtla, the deal comes about 6 months after the company raised $30 million in equity from an undisclosed group of Chinese investors. The company, founded in 2007, operates out of San Diego with labs in Beijing.
By Damian Garde
Source: Fierce Biotech
The companies will explore opportunities to apply Flagship’s innovative bioplatforms – an ecosystem that currently comprises 41 companies – to scientific challenges in disease areas within cardiometabolic and rare diseases and initiate research programmes based on these.
BD is expanding its long-running partnership with the blood collection company Babson Diagnostics. The two companies have been working together since 2019 on a device that can gather small volumes of blood from the capillaries in the fingertip without requiring any specialized training, and beginning with a focus on supporting primary care in retail settings.
Wednesday, Australian biotech CSL said (PDF) the regulatory review of its $11.7 billion acquisition of Switzerland’s Vifor Pharma will take “a few more months,” suggesting it won’t be able to close the transaction by June 2022 as previously expected.
