Sector News

Oxford BioMedica signs major supply deal with Novartis

July 7, 2017
Life sciences

Oxford BioMedica has sealed a major deal with Novartis to supply the Swiss drug giant with lentiviral vectors used to create cell therapy products, including CTL019 and other undisclosed Chimeric Antigen Receptor T cell (CART) products.

The agreement builds on the collaboration announced between the group and Novartis in October 2014 and anticipates the commercial launch of CTL019 later this year for the blood cancer B-cell acute lymphoblastic leukaemia.

The deal could see Oxford BioMedica bank in excess of $100 million from Novartis over the next three years, including a $10 million upfront payment, various performance incentives and bioprocessing and development services.

In addition the UK group will also receive undisclosed royalties on potential future sales of Novartis’s CAR-T products.

Initially the supply agreement will run for three years, but this could be extended to five years subject to the wishes of both parties.

The deal, says Oxford BioMedica’s chief executive John Dawson, “demonstrates the value of our LentiVector platform and the quality of work we have delivered to Novartis over the last few years.

“The new deal with Novartis will strengthen the Group’s balance sheet immediately and will support the Group’s continued growth over the next three years.”

CAR-T offers a new treatment approach in that it is specifically manufactured for each individual patient. During the process, T cells are drawn from a patient’s blood and reprogrammed in the laboratory to create T cells that are genetically coded to hunt the patient’s cancer cells and other B-cells expressing a particular antigen.

Novartis picked up rights to CTL019 under an agreement with the University of Pennsylvania in 2012, which also gives it worldwide rights to CARTs developed in all cancer indications.

By Selina McKee

Source: Pharma Times

comments closed

Related News

September 25, 2022

Rise of the machines: Novo Nordisk pledges $200M to create first quantum computer for life sciences

Life sciences

Big Pharma has long seen the potential for AI and machine learning to accelerate drug development. But Novo Nordisk is going a step further by channeling $200 million toward the creation of a computer that will outrun anything in existence.

September 25, 2022

Mount Sinai AI uncovers new brain analysis method to predict dementia, Alzheimer’s disease

Life sciences

Current methods for diagnosing Alzheimer’s disease rely on a complex combination of self- and caregiver-reported symptoms, a physical examination and either a PET scan or a spinal tap to look for evidence of amyloid plaque build-ups in the brain. But a new artificial intelligence-based method may make the diagnostic process a much more objective one.

September 25, 2022

New AstraZeneca-backed report finds big money behind diverse owners and entrepreneurs in Europe

Life sciences

There is lots of talk about diversity and inclusion in business, including in pharma and medtech. A new report by the Open Political Economy Network (OPEN), a think tank focusing on migration and diversity, released its “Minority Businesses Matter: Europe” report highlighting the successes and challenges of ethnic minority-owned businesses in Europe.