Sector News

NIH scientists move closer to vaccine holy grail: a universal flu shot

July 14, 2022
Life sciences

Researchers at the National Institutes of Health (NIH) are moving closer to the holy grail of the vaccine world: a universal flu shot.

An experimental vaccine from the NIH’s National Institute of Allergy and Infectious Diseases that protects against strains of influenza A virus in animal models is now moving into human studies. The shot has been shown to protect mice and ferrets from four strains of the influenza A virus, including potentially fatal strains from birds and pig, according to findings published July 13 in Science.

The seasonal flu causes as many as 650,000 global deaths each year. Because the virus mutates so quickly, a new vaccine must be developed every year, making it difficult to protect against the infection in the long term. Moreover, annual vaccines only fight circulating human strains and don’t offer protection against other strains that can emerge from animals.

To combat some of these issues, the NIH researchers developed a flu vaccine consisting of inactivated whole-virus avian subtypes of influenza A, which makes up most flu cases. Composed of subtypes H1N9, H3N8, H5N1 and H7N3, the vaccine also includes multiple viral proteins that trigger widely protective B- and T-cell responses.

The vaccine, which can be administered via injection or intranasally, protected mice and ferrets from various human, pig and bird flu strains. Compared to the control animals, vaccinated animals showed significant reductions in viral titers, lung pathology and host inflammatory responses.

The way the researchers created the vaccine is similar to current methods of production for seasonal flu vaccines, meaning manufacturing the candidate could be relatively simple and inexpensive. Additionally, no toxicity was observed in mice, ferrets or rabbits receiving the vaccine, suggesting that the candidate is likely safe in humans—although testing will, of course, be required.

The FDA has already approved an application to study the experimental vaccine in humans, with an initial phase 1 safety and immunogenicity study beginning this June at the NIH Clinical Center.

Researchers across the world have been attempting for years to develop a universal flu vaccine as it could spare scientists and pharmaceutical companies from the often inaccurate process of predicting the circulating strains each year and redesigning a vaccine to match them.

The new candidate could have broad application as both a prepandemic and a superseasonal flu vaccine that could be low-cost and easily distributed worldwide, the authors concluded.

By Gabrielle Masson


comments closed

Related News

November 27, 2022

DSM-Firmenich nutrition and beauty mega-merger edges closer as companies announce Exchange Offer

Life sciences

The new company will have four complementary businesses: Perfumery & Beauty, Food & Beverage/Taste & Beyond, Health, Nutrition & Care and Animal Nutrition & Health, each with strong market positions and expertise to address emerging consumer trends. The businesses will also prioritize environmental sustainability, health and well-being.

November 27, 2022

Merck agrees to acquire Imago for $1.35bn

Life sciences

Merck (MSD) has signed a definitive agreement for the acquisition of all outstanding shares of Imago BioSciences for a total equity price of nearly $1.35bn. A clinical-stage biopharmaceutical firm, Imago focuses on the development of new therapies to treat myeloproliferative neoplasms (MPNs) and other bone marrow ailments.

November 27, 2022

Novo Nordisk expands API capacity

Life sciences

Danish pharma Novo Nordisk has announced plans to invest 5.4 billion Danish kroner to expand its existing facilities in Bagsværd. The project will establish extra R&D capacity for manufacturing APIs to supply the company’s global clinical trials for oral and injectable products. The expansion is expected to be finished in 2024, creating about 160 new jobs.