The National Institute for Health and Care Excellence (NICE) has published guidance recommending the use of Pfizer’s Lorviqua (lorlatinib) for a certain form of lung cancer on the NHS.
The drug has been recommended, within its marketing authorisation, as an option for treating anaplastic lymphoma kinase (ALK)-positive advanced non-small-cell lung cancer (NSCLC) in adults whose disease has progressed after: alectinib or ceritinib as the first ALK tyrosine kinase inhibitor; or crizotinib and at least one other ALK tyrosine kinase inhibitor.
Lorviqua, which is also an ALK tyrosine kinase inhibitor, has not been compared directly with other drugs. But according to NICE, analyses indirectly comparing the drug with platinum doublet chemotherapy (PDC) and atezolizumab with bevacizumab, carboplatin and paclitaxel (ABCP) suggest that people who take Lorviqua experience benefits in disease progression and survival.
Moreover, the drug meets NICE’s criteria to be considered a life-extending treatment at the end of life and, while cost-effectiveness remains uncertain, the most likely estimates are within what the Institute normally considers an acceptable use of NHS resources, it said.
By: Selina McKee
Source: Pharma Times
The Food and Drug Administration’s top scientist Namandjé Bumpus will assume the role of principal deputy commissioner when longtime agency leader Janet Woodcock retires from that role in early 2024, according to an announcement Thursday.
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EUROAPI today announced the appointment of David Seignolle as Chief Operating Officer, succeeding Eric Berger, and Marion Santin as Chief Legal, Compliance, and IP Officer, both joining the company’s Executive Committee. In his new role, David Seignolle will lead the transformation of the Industrial Operations organization.