Sector News

Eli Lilly, Amgen join forces to scale production of COVID-19 antibody cocktails

September 18, 2020
Life sciences

Months of fervid research have whittled away most potential options to treat patients with COVID-19, a group of antibody cocktails still hold promise. Eli Lilly believes so strongly in its contender that it’s bringing on a major pharma partner to chip in on production.

Eli LIlly and Amgen have teamed up to scale manufacturing of future antibody cocktails, including Lilly’s LY-CoV-55, in testing to treat COVID-19, the partners said Thursday.

In a joint statement slim on details, both drugmakers pledged only to “quickly scale up production” of a range of neutralizing antibodies Lilly is studying to treat COVID-19—if any get over the regulatory finish line, that is.

The most promising of those candidates is LY-CoV-555, an AbCellera-partnered cocktail that entered phase 3 human testing in August. Lilly is also developing LY-CoV016 through a licensing deal with China’s Junshi Biosciences and has launched a phase 2 trial testing a combination of the two in patients with early, mild to moderate COVID-19.

An Amgen spokesman declined in an email to offer further details on the deal.

So far, Lilly’s lead antibody candidate has shown mixed promise in human tests, with data from a phase 2 trial release this week showing two of three tested doses didn’t top placebo in reducing patients’ viral load at the 11-day mark.

Only the 2,800-milligram dose met the primary endpoint. The other two doses—700 milligrams and 7,000 milligrams—did no better than placebo. Typically, the highest dose of a drug has the biggest effect.

It’s not the first time during the novel coronavirus pandemic that Lilly and Amgen have combined forces to boost COVID-fighting antibodies.

In late June, both drugmakers joined a brain trust alongside AstraZeneca, GlaxoSmithKline, Roche’s Genentech and AbCellera to share monoclonal antibody manufacturing secrets in an effort to get each member up to speed on manufacturing best practices.

The unusual arrangement won the backing of the Department of Justice’s antitrust division, which said in a statement at the time that all six drugmakers wouldn’t be allowed to discuss pricing as part of their collab.

The deal notably didn’t include Regeneron and its advanced antibody cocktail, which carries sales hopes of $6 billion per year after the New York drugmaker reached an expansive global manufacturing tie-up with Roche in August.

Alongside its own antibody aims, Lilly has found a foothold in repurposing rheumatoid arthritis med Olumiant to treat COVID-19. The med, added to Gilead’s Veklury (remdesivir), posted promising trial results earlier this week.

In data unveiled Monday, patients treated with with an Olumiant-Veklury combo recovered faster than those on Gilead’s drug alone. The difference was about one day at the median, significant enough to prompt Lilly to take the data to the FDA for a possible emergency approval.

If Olumiant succeeds, it would become the third therapy with an early approval to treat COVID-19 alongside Veklury and convalescent plasma.

By: Kyle Blankenship

Source: Fierce Pharma

comments closed

Related News

September 25, 2022

Rise of the machines: Novo Nordisk pledges $200M to create first quantum computer for life sciences

Life sciences

Big Pharma has long seen the potential for AI and machine learning to accelerate drug development. But Novo Nordisk is going a step further by channeling $200 million toward the creation of a computer that will outrun anything in existence.

September 25, 2022

Mount Sinai AI uncovers new brain analysis method to predict dementia, Alzheimer’s disease

Life sciences

Current methods for diagnosing Alzheimer’s disease rely on a complex combination of self- and caregiver-reported symptoms, a physical examination and either a PET scan or a spinal tap to look for evidence of amyloid plaque build-ups in the brain. But a new artificial intelligence-based method may make the diagnostic process a much more objective one.

September 25, 2022

New AstraZeneca-backed report finds big money behind diverse owners and entrepreneurs in Europe

Life sciences

There is lots of talk about diversity and inclusion in business, including in pharma and medtech. A new report by the Open Political Economy Network (OPEN), a think tank focusing on migration and diversity, released its “Minority Businesses Matter: Europe” report highlighting the successes and challenges of ethnic minority-owned businesses in Europe.