(RTTNews) – Bristol-Myers Squibb Co. (BMY) and private biotechnology company Cardioxyl Pharmaceuticals, Inc. Monday announced a definitive agreement by which Bristol-Myers Squibb will acquire Cardioxyl focused on innovative drugs for treatment of cardiovascular disease.
The transaction is expected to be dilutive to 2015 earnings per share by around 12 cents, with minimal dilution to adjusted earnings both in 2015 and 2016. The deal has been approved by the boards of directors of both companies.
As per the agreement, Bristol-Myers Squibb will get full rights of Cardioxyl’s lead asset CXL-1427 in Phase 2 clinical development as an intravenous treatment for acute decompensated heart failure. The transaction includes upfront and near-term milestone payments of up to $300 million and potential additional consideration of up to $1.775 billion upon the achievement certain milestones.
CXL-1427 releases nitroxyl, a molecule that has demonstrated beneficial effects on heart muscle and vascular function and it help increase the heart muscle contraction and relaxation without increasing heart rate or the demand for oxygen.
The transaction is expected to close during the fourth quarter of 2015 on customary closing conditions, including clearance under the Hart-Scott-Rodino Antitrust Improvements Act.
The U.S. Patent and Trademark Office issued a patent to MedTrace for their method of diagnosing the human heart via 15O-water PET. The patented method is the foundation of the company’s software aQuant, currently under development. Hendrik “Hans” Harms, PhD and Senior Scientist at MedTrace, and Jens Soerensen, Professor and Clinical Advisor to MedTrace, are the originators of the method.
Teresa Graham, currently head of global product strategy for Roche pharma, will become the division’s new CEO next month, Roche said Thursday. Simultaneously, Roche is elevating Levi Garraway, chief medical officer, to the executive committee.
Fierce Pharma has obtained internal documents and video of a town hall meeting conducted this week describing what J&J called a “comprehensive review” of its portfolio. Moving forward, J&J plans to operate its vaccines and infectious diseases outfits as one group, the executives explained.